Long-lived men healthier than female counterparts: study

KUNMING -- Chinese researchers have recently discovered that unique DNA methylation characteristics in long-lived men grant them better health compared to female counterparts of the same age.

DNA methylation is an epigenetic mechanism that involves adding a methyl group to the DNA molecule. This biochemical process can influence gene expression without altering the DNA sequence itself.

"DNA methylation is closely related to human aging and the occurrence of age-related diseases," said Xiao Fuhui, an associate researcher at the Kunming Institute of Zoology under the Chinese Academy of Sciences.

Researchers from the institute performed whole-genome bisulfite sequencing on long-lived men, long-lived women, younger men and younger women to explore specific methylation characteristics in long-lived men.

They discovered that the genomes of male long-lived individuals possess specific DNA methylation units. These units can regulate the expression of genes associated with age-related diseases, thereby inhibiting the occurrence of conditions such as tumors. This results in lower disease incidence and better physical functioning among male long-lived individuals.

The study results have been published in the journal Cell Reports.