His obstetrician, Dr. Kimberly James, who practices in the Oregon town, told Winfrey, "This is a normal pregnancy."
She said Beatie stopped taking testosterone two years ago and his levels of the hormone are normal.
"This baby is totally healthy," she said. "This is what I consider a normal pregnancy."
The couple said they had been turned down by a number of other doctors before James agreed to take him as a patient.
The couple said an earlier attempt at pregnancy failed when he developed a tubal pregnancy, resulting in surgery that removed his Fallopian tubes.
The couple said they decided to go public with the pregnancy because they wanted to control the way the news got out. "We're just going to have the baby now," Nancy said. "If we have to, we'll go hide."
The couple runs a small business in Bend and has some savings, she said. In addition, Beatie is working on a book about his childhood, his mother's suicide and his life growing in Hawaii where, as a girl, he was a teen beauty pageant contestant and earned a martial arts black belt.
Winfrey called the development "a new definition of what diversity means for everybody."
