Anna Nicole Smith poses as Marilyn Monroe for a 2004 PETA ad campaign in this handout picture.[Reuters]

She was stricken while staying at the Seminole Hard Rock Hotel and Casino and was rushed to a hospital. Edwina Johnson, chief investigator for the Broward County Medical Examiner's Office, said the cause of death was under investigation and an autopsy would be done on Friday.

Just five months ago, Smith's 20-year-old son, Daniel, died suddenly in the Bahamas in what was believed to be a drug-related death.

Seminole Police Chief Charlie Tiger said a private nurse called 911 after finding Smith unresponsive in her sixth-floor room at the hotel, which is on an Indian reservation. He said Smith's bodyguard administered CPR, but she was declared dead at a hospital.

Dr. Joshua Perper, the chief Broward County medical examiner who will perform the autopsy, said if her death was from natural causes, the findings would likely be announced quickly. He cautioned, however, that definitive results could take weeks.

"I am not a prophet, and I cannot tell you before the autopsy what I am going to find," he said.

Through the '90s and into the new century, Smith was famous for being famous, a pop-culture punchline because of her up-and-down weight, her Marilyn Monroe looks, her exaggerated curves, her little-girl voice, her ditzy-blonde persona, and her over-the-top revealing outfits.

Recently, she lost a reported 69 pounds and became a spokeswoman for TrimSpa, a weight-loss supplement. On her reality show and other recent TV appearances, her speech was often slurred and she seemed out of it. Some critics said she seemed drugged-out.

"Undoubtedly it will be found at the end of the day that drugs featured in her death as they did in the death of poor Daniel," said a former attorney for Smith in the Bahamas, Michael Scott.

Another former Smith attorney, Lenard Leeds, told the celebrity gossip Web site TMZ that Smith "always had problems with her weight going up and down, and there's no question she used alcohol." Leeds said it was no secret that "she had a very troubled life" and had "so many, many problems."

Smith attorney Ron Rale told The Associated Press that he had talked to her on Tuesday or Wednesday, and she had flu symptoms and a fever and was still grieving over her son.

"Poor Anna Nicole," he said. "She's been the underdog. She's been besieged ... and she's been trying her best and nobody should have to endure what she's endured."

The Texas-born Smith was a topless dancer at strip club before she entered her photos in a search contest and made the cover of Playboy magazine in 1992. She became Playboy's playmate of the year in 1993. She was also signed to a contract with Guess jeans, appearing in TV commercials, billboards and magazine ads.

In 1994, she married 89-year-old oil tycoon J. Howard Marshall II, owner of Great Northern Oil Co. In 1992, Forbes magazine estimated his wealth at $550 million.

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