CHICAGO - The higher a pregnant woman's level of blood sugar, the greater the risk to her newborn - whether the mother has diabetes or not, the largest study on the problem suggests. The findings released Friday may lead to more women being diagnosed with diabetes during pregnancy and given stricter diet advice or medication to lower blood sugar.

The research involved more than 23,000 pregnant women in nine countries. It found a surprisingly strong relationship between the blood sugar levels of the women and the rate of big babies and first-time Caesarean sections, said lead investigator Dr. Boyd Metzger of Northwestern University.

The newborns also were more likely to have low blood sugar levels and high insulin levels if their mothers' blood sugar levels were higher. The problems can lead to obesity, diabetes and high blood pressure later in life.

Large babies risk shoulder damage and other injuries if delivered vaginally and lead to more C-sections, which also pose health risks to mothers and babies.

Large babies were defined in the study as those bigger than 90 percent of those born in the local population, so large Thai babies would be smaller than large US babies.

Researchers reported the findings Friday at the American Diabetes Association's annual scientific meeting.

The higher the mother's blood sugar, the more risk for the newborns, the study found. Researchers took into account obesity, age and family history of diabetes and still found the mother's blood sugar independently affected the infant's size and health.

It's long been known that gestational diabetes - a type of diabetes that starts during pregnancy and often goes away after birth - is unhealthy for a woman and her baby. The study is the largest to document the frequency of newborn problems at increasing levels in mother's blood sugar and the first to find that levels now considered acceptable posed some risks.

"We have established without any question that levels of blood sugar less elevated than typical diabetes carry risks," Metzger said. Currently, the goal for a pregnant woman's fasting blood sugar is below 95 milligrams per deciliter during the final few months of pregnancy.

1

2